Mutation of the LXCXE Binding Cleft of pRb Facilitates Transformation by ras In Vitro but Does Not Promote Tumorigenesis In Vivo

BACKGROUND: The Retinoblastoma protein (pRB) is a key tumor suppressor that is functionally inactivated in most cancers. pRB regulates the cell division cycle and cell cycle exit through protein–protein interactions mediated by its multiple binding interfaces. The LXCXE binding cleft region of pRB m...

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Detalles Bibliográficos
Autores principales: Talluri, Srikanth, Francis, Sarah M., Dick, Frederick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735560/
https://www.ncbi.nlm.nih.gov/pubmed/23936539
http://dx.doi.org/10.1371/journal.pone.0072236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735560/
https://www.ncbi.nlm.nih.gov/pubmed/23936539
http://dx.doi.org/10.1371/journal.pone.0072236

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