Slx8 Removes Pli1-Dependent Protein-SUMO Conjugates Including SUMOylated Topoisomerase I to Promote Genome Stability

The SUMO-dependent ubiquitin ligase Slx8 plays key roles in promoting genome stability, including the processing of trapped Topoisomerase I (Top1) cleavage complexes and removal of toxic SUMO conjugates. We show that it is the latter function that constitutes Slx8's primary role in fission yeas...

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Detalles Bibliográficos
Autores principales: Steinacher, Roland, Osman, Fekret, Lorenz, Alexander, Bryer, Claire, Whitby, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735562/
https://www.ncbi.nlm.nih.gov/pubmed/23936535
http://dx.doi.org/10.1371/journal.pone.0071960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735562/
https://www.ncbi.nlm.nih.gov/pubmed/23936535
http://dx.doi.org/10.1371/journal.pone.0071960

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