Phenotypic Switching Induced by Damaged Matrix Is Associated with DNA Methyltransferase 3A (DNMT3A) Activity and Nuclear Localization in Smooth Muscle Cells (SMC)

Extracellular matrix changes are often crucial inciting events for fibroproliferative disease. Epigenetic changes, specifically DNA methylation, are critical factors underlying differentiated phenotypes. We examined the dependency of matrix-induced fibroproliferation and SMC phenotype on DNA methylt...

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Detalles Bibliográficos
Autores principales: Jiang, Jia-Xin, Aitken, Karen J., Sotiropolous, Chris, Kirwan, Tyler, Panchal, Trupti, Zhang, Nicole, Pu, Shuye, Wodak, Shoshana, Tolg, Cornelia, Bägli, Darius J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735580/
https://www.ncbi.nlm.nih.gov/pubmed/24282625
http://dx.doi.org/10.1371/journal.pone.0069089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735580/
https://www.ncbi.nlm.nih.gov/pubmed/24282625
http://dx.doi.org/10.1371/journal.pone.0069089

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