Autophagic Impairment Contributes to Systemic Inflammation-Induced Dopaminergic Neuron Loss in the Midbrain

BACKGROUND: Neuroinflammation plays an important role in the pathogenesis of Parkinson’s disease (PD), inducing and accelerating dopaminergic (DA) neuron loss. Autophagy, a critical mechanism for clearing misfolded or aggregated proteins such as α-synuclein (α-SYN), may affect DA neuron survival in...

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Detalles Bibliográficos
Autores principales: Zheng, Hui-Fen, Yang, Ya-Ping, Hu, Li-Fang, Wang, Mei-Xia, Wang, Fen, Cao, Li-Dan, Li, Da, Mao, Cheng-Jie, Xiong, Kang-Ping, Wang, Jian-Da, Liu, Chun-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735600/
https://www.ncbi.nlm.nih.gov/pubmed/23936437
http://dx.doi.org/10.1371/journal.pone.0070472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735600/
https://www.ncbi.nlm.nih.gov/pubmed/23936437
http://dx.doi.org/10.1371/journal.pone.0070472

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