The Polymorphic AluYb8 Insertion in the MUTYH Gene is Associated with Reduced Type 1 Protein Expression and Reduced Mitochondrial DNA Content

The human mutY homolog (MUTYH) participates in base excision repair (BER), which is critical for repairing oxidized DNA bases and maintaining DNA replication fidelity. The polymorphic AluYb8 insertion in the 15(th) intron of the MUTYH gene (AluYb8MUTYH) has been shown to associate with an aggregated...

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Detalles Bibliográficos
Autores principales: Guo, Wenwen, Zheng, Bixia, Cai, Zhenming, Xu, Lizhi, Guo, Dong, Cao, Lili, Wang, Yaping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735632/
https://www.ncbi.nlm.nih.gov/pubmed/23936466
http://dx.doi.org/10.1371/journal.pone.0070718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735632/
https://www.ncbi.nlm.nih.gov/pubmed/23936466
http://dx.doi.org/10.1371/journal.pone.0070718

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