Induction of prolonged early G(1) arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1

Phosphatidylinositol-3-kinase (PI3K) signaling is constitutive in most human cancers. Selective inhibition of PI3Kδ (p110δ) by GS-1101 has emerged as a promising therapy in chronic lymphocytic leukemia and indolent lymphomas. In aggressive non-Hodgkin lymphomas such as mantle cell lymphoma (MCL), ho...

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Detalles Bibliográficos
Autores principales: Chiron, David, Martin, Peter, Di Liberto, Maurizio, Huang, Xiangao, Ely, Scott, Lannutti, Brian J., Leonard, John P., Mason, Christopher E., Chen-Kiang, Selina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735703/
https://www.ncbi.nlm.nih.gov/pubmed/23676220
http://dx.doi.org/10.4161/cc.24928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735703/
https://www.ncbi.nlm.nih.gov/pubmed/23676220
http://dx.doi.org/10.4161/cc.24928

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