The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit

Reversible ubiquitylation of proteins contributes to their integrity, abundance and activity. The RE1-silencing transcription factor (REST) plays key physiological roles and is dysregulated in a spectrum of disease. It is rapidly turned over and is phosphorylated, polyubiquitylated and degraded en m...

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Detalles Bibliográficos
Autores principales: Faronato, Monica, Patel, Vruti, Darling, Sarah, Dearden, Laura, Clague, Michael J., Urbé, Sylvie, Coulson, Judy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735711/
https://www.ncbi.nlm.nih.gov/pubmed/23708518
http://dx.doi.org/10.4161/cc.25035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735711/
https://www.ncbi.nlm.nih.gov/pubmed/23708518
http://dx.doi.org/10.4161/cc.25035

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