Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity
Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity. Thus, the present study evaluated th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736522/ https://www.ncbi.nlm.nih.gov/pubmed/23970936 http://dx.doi.org/10.1155/2013/795916 |
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author | Nishimura, Francielli de Cássia Yukari de Almeida, Ana Carolina Ratti, Bianca Altrão Ueda-Nakamura, Tânia Nakamura, Celso Vataru Ximenes, Valdecir Farias Silva, Sueli de Oliveira |
author_facet | Nishimura, Francielli de Cássia Yukari de Almeida, Ana Carolina Ratti, Bianca Altrão Ueda-Nakamura, Tânia Nakamura, Celso Vataru Ximenes, Valdecir Farias Silva, Sueli de Oliveira |
author_sort | Nishimura, Francielli de Cássia Yukari |
collection | PubMed |
description | Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity. Thus, the present study evaluated the effects of naringenin and quercetin on ROS production, specifically hypochlorous acid (HOCl), and their involvement in the microbicidal activity of neutrophils. Naringenin and quercetin inhibited HOCl production through different systems, but this inhibition was more pronounced for quercetin, even in the cell-free systems. With regard to the microbicidal activity of neutrophils, both naringenin and quercetin completely inhibited the killing of Staphylococcus aureus. Altogether, these data indicate that the decrease in the oxidant activity of neutrophils induced by these compounds directly impaired the microbicidal activity of neutrophils. Naringenin and quercetin exerted their effects by controlling the effector mechanisms of ROS production, with both positive and negative effects of these antioxidant agents in oxidative stress conditions and on ROS in the microbicidal activity of phagocytes. The present results challenge the traditional view of antioxidants as improvers of pathological conditions. |
format | Online Article Text |
id | pubmed-3736522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37365222013-08-22 Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity Nishimura, Francielli de Cássia Yukari de Almeida, Ana Carolina Ratti, Bianca Altrão Ueda-Nakamura, Tânia Nakamura, Celso Vataru Ximenes, Valdecir Farias Silva, Sueli de Oliveira Evid Based Complement Alternat Med Research Article Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity. Thus, the present study evaluated the effects of naringenin and quercetin on ROS production, specifically hypochlorous acid (HOCl), and their involvement in the microbicidal activity of neutrophils. Naringenin and quercetin inhibited HOCl production through different systems, but this inhibition was more pronounced for quercetin, even in the cell-free systems. With regard to the microbicidal activity of neutrophils, both naringenin and quercetin completely inhibited the killing of Staphylococcus aureus. Altogether, these data indicate that the decrease in the oxidant activity of neutrophils induced by these compounds directly impaired the microbicidal activity of neutrophils. Naringenin and quercetin exerted their effects by controlling the effector mechanisms of ROS production, with both positive and negative effects of these antioxidant agents in oxidative stress conditions and on ROS in the microbicidal activity of phagocytes. The present results challenge the traditional view of antioxidants as improvers of pathological conditions. Hindawi Publishing Corporation 2013 2013-07-21 /pmc/articles/PMC3736522/ /pubmed/23970936 http://dx.doi.org/10.1155/2013/795916 Text en Copyright © 2013 Francielli de Cássia Yukari Nishimura et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Nishimura, Francielli de Cássia Yukari de Almeida, Ana Carolina Ratti, Bianca Altrão Ueda-Nakamura, Tânia Nakamura, Celso Vataru Ximenes, Valdecir Farias Silva, Sueli de Oliveira Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity |
title | Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity |
title_full | Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity |
title_fullStr | Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity |
title_full_unstemmed | Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity |
title_short | Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity |
title_sort | antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736522/ https://www.ncbi.nlm.nih.gov/pubmed/23970936 http://dx.doi.org/10.1155/2013/795916 |
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