Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity

Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity. Thus, the present study evaluated th...

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Autores principales: Nishimura, Francielli de Cássia Yukari, de Almeida, Ana Carolina, Ratti, Bianca Altrão, Ueda-Nakamura, Tânia, Nakamura, Celso Vataru, Ximenes, Valdecir Farias, Silva, Sueli de Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736522/
https://www.ncbi.nlm.nih.gov/pubmed/23970936
http://dx.doi.org/10.1155/2013/795916
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author Nishimura, Francielli de Cássia Yukari
de Almeida, Ana Carolina
Ratti, Bianca Altrão
Ueda-Nakamura, Tânia
Nakamura, Celso Vataru
Ximenes, Valdecir Farias
Silva, Sueli de Oliveira
author_facet Nishimura, Francielli de Cássia Yukari
de Almeida, Ana Carolina
Ratti, Bianca Altrão
Ueda-Nakamura, Tânia
Nakamura, Celso Vataru
Ximenes, Valdecir Farias
Silva, Sueli de Oliveira
author_sort Nishimura, Francielli de Cássia Yukari
collection PubMed
description Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity. Thus, the present study evaluated the effects of naringenin and quercetin on ROS production, specifically hypochlorous acid (HOCl), and their involvement in the microbicidal activity of neutrophils. Naringenin and quercetin inhibited HOCl production through different systems, but this inhibition was more pronounced for quercetin, even in the cell-free systems. With regard to the microbicidal activity of neutrophils, both naringenin and quercetin completely inhibited the killing of Staphylococcus aureus. Altogether, these data indicate that the decrease in the oxidant activity of neutrophils induced by these compounds directly impaired the microbicidal activity of neutrophils. Naringenin and quercetin exerted their effects by controlling the effector mechanisms of ROS production, with both positive and negative effects of these antioxidant agents in oxidative stress conditions and on ROS in the microbicidal activity of phagocytes. The present results challenge the traditional view of antioxidants as improvers of pathological conditions.
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spelling pubmed-37365222013-08-22 Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity Nishimura, Francielli de Cássia Yukari de Almeida, Ana Carolina Ratti, Bianca Altrão Ueda-Nakamura, Tânia Nakamura, Celso Vataru Ximenes, Valdecir Farias Silva, Sueli de Oliveira Evid Based Complement Alternat Med Research Article Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity. Thus, the present study evaluated the effects of naringenin and quercetin on ROS production, specifically hypochlorous acid (HOCl), and their involvement in the microbicidal activity of neutrophils. Naringenin and quercetin inhibited HOCl production through different systems, but this inhibition was more pronounced for quercetin, even in the cell-free systems. With regard to the microbicidal activity of neutrophils, both naringenin and quercetin completely inhibited the killing of Staphylococcus aureus. Altogether, these data indicate that the decrease in the oxidant activity of neutrophils induced by these compounds directly impaired the microbicidal activity of neutrophils. Naringenin and quercetin exerted their effects by controlling the effector mechanisms of ROS production, with both positive and negative effects of these antioxidant agents in oxidative stress conditions and on ROS in the microbicidal activity of phagocytes. The present results challenge the traditional view of antioxidants as improvers of pathological conditions. Hindawi Publishing Corporation 2013 2013-07-21 /pmc/articles/PMC3736522/ /pubmed/23970936 http://dx.doi.org/10.1155/2013/795916 Text en Copyright © 2013 Francielli de Cássia Yukari Nishimura et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nishimura, Francielli de Cássia Yukari
de Almeida, Ana Carolina
Ratti, Bianca Altrão
Ueda-Nakamura, Tânia
Nakamura, Celso Vataru
Ximenes, Valdecir Farias
Silva, Sueli de Oliveira
Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity
title Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity
title_full Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity
title_fullStr Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity
title_full_unstemmed Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity
title_short Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity
title_sort antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736522/
https://www.ncbi.nlm.nih.gov/pubmed/23970936
http://dx.doi.org/10.1155/2013/795916
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