The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

Autophagy is a catabolic process for bulk degradation of cytosolic materials mediated by double-membraned autophagosomes. The membrane determinant to initiate the formation of autophagosomes remains elusive. Here, we establish a cell-free assay based on LC3 lipidation to define the organelle membran...

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Detalles Bibliográficos
Autores principales: Ge, Liang, Melville, David, Zhang, Min, Schekman, Randy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736544/
https://www.ncbi.nlm.nih.gov/pubmed/23930225
http://dx.doi.org/10.7554/eLife.00947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736544/
https://www.ncbi.nlm.nih.gov/pubmed/23930225
http://dx.doi.org/10.7554/eLife.00947

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