Cargando…

In-vitro/In-vivo comparison of leuprolide acetate release from an in-situ forming plga system

A poly (lactide-co-glycolide) (PLGA) implant was used to control the release profile of leuprolide acetate (LA) drug. The system is an in-situ polymeric precipitation system. And the formulation consisted of PLGA polymer, LA drug and N-methyl-2-pyrrolidon solvent with no additives. First, the formul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mashayekhi, Roya, Mobedi, Hamid, Najafi, Jamal, Enayati, Marjan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737027/ https://www.ncbi.nlm.nih.gov/pubmed/23856431 http://dx.doi.org/10.1186/2008-2231-21-57

Ejemplares similares

Injectable In-Situ Forming Depot Based on PLGA and PLGA-PEG-PLGA for Sustained-Release of Risperidone: In Vitro Evaluation and Pharmacokinetics in Rabbits
por: Rezaeian Shiadeh, Seyedeh Nesa, et al.
Publicado: (2023)

Evaluation of Hypersensitivity Reactions with Leuprolide Acetate and Triptorelin Acetate in Children
por: Metbulut, Azize Pınar, et al.
Publicado: (2021)

Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia
por: Choi, Jong Hyuk, et al.
Publicado: (2018)

Pseudotumor cerebri in patient on leuprolide acetate for central precocious puberty
por: Omar, Anjumanara Anver, et al.
Publicado: (2020)

Clinical development of the GnRH agonist leuprolide acetate depot
por: Chwalisz, Kristof
Publicado: (2022)

Sustained in vitro interferon-beta release and in vivo toxicity of PLGA and PEG-PLGA nanoparticles
por: Fodor-Kardos, Andrea, et al.
Publicado: (2020)

Leuprolide acetate induces structural and functional recovery of injured spinal cord in rats
por: Díaz Galindo, Carmen, et al.
Publicado: (2015)

Leuprolide Acetate 1-Month Depot for Central Precocious Puberty: Hormonal Suppression and Recovery
por: Neely, E. Kirk, et al.
Publicado: (2010)

In Situ-Forming Microparticles for Controlled Release of Rivastigmine: In Vitro Optimization and In Vivo Evaluation
por: Haider, Mohamed, et al.
Publicado: (2021)

Efficacy and safety of leuprolide acetate 6-month depot for suppression of testosterone in patients with prostate cancer
por: Spitz, A, et al.
Publicado: (2012)

Analysis of Adherence, Persistence, and Surgery Among Endometriosis Patients Treated with Leuprolide Acetate Plus Norethindrone Acetate Add-Back Therapy
por: Soliman, Ahmed M., et al.
Publicado: (2016)

Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection
por: Hao, Linkun, et al.
Publicado: (2021)

Inflammatory myopathy and severe rhabdomyolysis induced by leuprolide acetate therapy for prostate cancer: a case report
por: Bergner, Michael, et al.
Publicado: (2011)

Effects of leuprolide acetate on the quality of life of patients with prostate cancer: A prospective longitudinal cohort study
por: Kim, Myung Soo, et al.
Publicado: (2021)

Subcutaneous in situ gel delivered leuprolide acetate's consistent and prolonged drug delivery maintains effective testosterone suppression independent of age and weight in men with prostate cancer
por: Renzulli, Joseph F., et al.
Publicado: (2020)

Development of Level A In Vitro–Vivo Correlation for Electrosprayed Microspheres Containing Leuprolide: Physicochemical, Pharmacokinetic, and Pharmacodynamic Evaluation
por: Lee, Dong-Seok, et al.
Publicado: (2020)

6-Month Subcutaneous Leuprolide Acetate Effectively Suppresses Clinical Signs of Puberty in Children With Central Precocious Puberty
por: Eugster, Erica A, et al.
Publicado: (2021)

Simulation of Drug Release from PLGA Particles In Vivo
por: Sasaki, Kaori, et al.
Publicado: (2013)

Mechanistic analysis of Zein nanoparticles/PLGA triblock in situ forming implants for glimepiride
por: Ahmed, Osama Abdelhakim Aly, et al.
Publicado: (2016)

Treatment with Depot Leuprolide Acetate in Girls with Idiopathic Precocious Puberty: What Parameter should be Used in Deciding on the Initial Dose?
por: Vurallı, Doğuş, et al.
Publicado: (2020)

Efficacy and Safety of Leuprolide Acetate 6-Month Depot for the Treatment of Central Precocious Puberty: A Phase 3 Study
por: Klein, Karen O, et al.
Publicado: (2023)

Phase 3 Trial of a Small-volume Subcutaneous 6-Month Duration Leuprolide Acetate Treatment for Central Precocious Puberty
por: Klein, Karen O, et al.
Publicado: (2020)

Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats
por: Anwer, Md Khalid, et al.
Publicado: (2019)

Preparation and Release Profiles in Vitro/Vivo of Galantamine Pamoate Loaded Poly (Lactideco-Glycolide) (PLGA) Microspheres
por: Du, Liping, et al.
Publicado: (2021)

Preparation and in vitro evaluation of injectable formulations of levothyroxine sodium using in situ forming hydrogel temperature-responsive systems based on PLA-PEG-PLA and PLGA-PEG-PLGA triblock copolymers
por: Movaffagh, Jebraeil, et al.
Publicado: (2022)

In Vitro and In Vivo Evaluations of PLGA Microspheres Containing Nalmefene
por: Xie, Xiangyang, et al.
Publicado: (2015)

Myocardial Infarction in a Premenopausal Woman on Leuprolide Therapy
por: Perez, Irving E., et al.
Publicado: (2015)

Bazedoxifene/conjugated estrogens in combination with leuprolide for the treatment of endometriosis
por: Hill, Amanda M., et al.
Publicado: (2018)

SUN-421 Leuprolide Injection Induced Pituitary Apoplexy
por: Jaggi, Shirin, et al.
Publicado: (2019)

Efficacy of Leuprolide Acetate 1-Month Depot for Central Precocious Puberty (CPP): Growth Outcomes During a Prospective, Longitudinal Study
por: Lee, Peter A, et al.
Publicado: (2011)

Multicenter clinical trial of leuprolide acetate depot (Luphere depot 3.75 mg) for efficacy and safety in girls with central precocious puberty
por: Kim, You Jin, et al.
Publicado: (2013)

Double-Controlled Release of Poorly Water-Soluble Paliperidone Palmitate from Self-Assembled Albumin-Oleic Acid Nanoparticles in PLGA in situ Forming Implant
por: Yu, Yongjun, et al.
Publicado: (2021)

Preparation and In-vitro Evaluation of Controlled Release PLGA Microparticles Containing Triptoreline
por: Mahboubian, Alireza, et al.
Publicado: (2010)

Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation
por: Hu, Sanyuan, et al.
Publicado: (2010)

Effect of Leuprolide Acetate, a GnRH Agonist, on Neuroinflammation and Anxiety-Like Behavior after Mild Hypoxic-Ischemic Encephalopathy in Rat Model
por: Pedroza-García, Karina Alejandra, et al.
Publicado: (2023)

Persistent genital arousal disorder: Successful treatment with leuprolide (antiandrogen)
por: Deka, Kamala, et al.
Publicado: (2015)

Testosterone-Mediated Aggression in Angelman Syndrome Treated With Leuprolide and Orchiectomy
por: Anderson, Danyon J, et al.
Publicado: (2022)

PMON70 Systemic Delivery of Leuprolide via Oral Administration
por: Shangold, Gary, et al.
Publicado: (2022)

Intra-articular injection PLGA blends sustained-release microspheres loaded with meloxicam: preparation, optimization, evaluation in vitro and in vivo
por: Sun, Zheng, et al.
Publicado: (2022)

A 6-month depot formulation of leuprolide acetate is safe and effective in daily clinical practice: a non-interventional prospective study in 1273 patients
por: Tunn, Ulf W
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_gm0g05h6ftafhd6404ggbsi5i2