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Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats

BACKGROUND: We have previously shown a sprouting of sympathetic fibers into the upper dermis of the skin following subcutaneous injection of complete Freund’s adjuvant (CFA) into the hindpaw. This sprouting correlated with an increase in pain-related sensitivity. We hypothesized that this sprouting...

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Detalles Bibliográficos
Autores principales: Osikowicz, Maria, Longo, Geraldine, Allard, Simon, Cuello, A Claudio, Ribeiro-da-Silva, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737061/
https://www.ncbi.nlm.nih.gov/pubmed/23889761
http://dx.doi.org/10.1186/1744-8069-9-37