The Fas/Fas Ligand Death Receptor Pathway Contributes to Phenylalanine-Induced Apoptosis in Cortical Neurons

Phenylketonuria (PKU), an autosomal recessive disorder of amino acid metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene, leads to childhood mental retardation by exposing neurons to cytotoxic levels of phenylalanine (Phe). A recent study showed that the mitochondria-mediated...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Xiaodong, Lu, Zhaohui, Lv, Zhongwei, Yu, Tingting, Yang, Peirong, Shen, Yongnian, Ding, Yu, Fu, Da, Zhang, Xiaoping, Fu, Qihua, Yu, Yongguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737091/
https://www.ncbi.nlm.nih.gov/pubmed/23940767
http://dx.doi.org/10.1371/journal.pone.0071553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737091/
https://www.ncbi.nlm.nih.gov/pubmed/23940767
http://dx.doi.org/10.1371/journal.pone.0071553

Ejemplares similares