The Genetic Architecture of Methotrexate Toxicity Is Similar in Drosophila melanogaster and Humans

The severity of the toxic side effects of chemotherapy varies among patients, and much of this variation is likely genetically based. Here, we use the model system Drosophila melanogaster to genetically dissect the toxicity of methotrexate (MTX), a drug used primarily to treat childhood acute lympho...

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Detalles Bibliográficos
Autores principales: Kislukhin, Galina, King, Elizabeth G., Walters, Kelli N., Macdonald, Stuart J., Long, Anthony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2013
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737169/
https://www.ncbi.nlm.nih.gov/pubmed/23733889
http://dx.doi.org/10.1534/g3.113.006619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737169/
https://www.ncbi.nlm.nih.gov/pubmed/23733889
http://dx.doi.org/10.1534/g3.113.006619

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