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TNF Stimulates Nuclear Export and Secretion of IL-15 by Acting on CRM1 and ARF6
Interleukin (IL)-15 is a ubiquitously expressed cytokine that in the basal state is mainly localized intracellularly, including the nucleus. Unexpectedly, tumor necrosis factor-α (TNF) time-dependently induced nuclear export of IL-15Rα and IL15. This process was inhibited by leptomycine B (LMB), a s...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737262/ https://www.ncbi.nlm.nih.gov/pubmed/23950892 http://dx.doi.org/10.1371/journal.pone.0069356 |