Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

Increased hepatic lipid content is an early correlate of insulin resistance, and can be caused by nutrient-induced mTor activation. The latter increases basal Akt activity, leading to a self-perpetuating lipogenic cycle. We have previously shown that the developmental Notch pathway has metabolic fun...

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Detalles Bibliográficos
Autores principales: Pajvani, Utpal B., Qiang, Li, Kangsamaksin, Thaned, Kitajewski, Jan, Ginsberg, Henry N., Accili, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737382/
https://www.ncbi.nlm.nih.gov/pubmed/23832089
http://dx.doi.org/10.1038/nm.3259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737382/
https://www.ncbi.nlm.nih.gov/pubmed/23832089
http://dx.doi.org/10.1038/nm.3259

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