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Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability
Increased hepatic lipid content is an early correlate of insulin resistance, and can be caused by nutrient-induced mTor activation. The latter increases basal Akt activity, leading to a self-perpetuating lipogenic cycle. We have previously shown that the developmental Notch pathway has metabolic fun...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737382/ https://www.ncbi.nlm.nih.gov/pubmed/23832089 http://dx.doi.org/10.1038/nm.3259 |