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The role of the C-terminal helix of U1A protein in the interaction with U1hpII RNA

Previous kinetic investigations of the N-terminal RNA Recognition Motif (RRM) domain of spliceosomal A protein of the U1 small nuclear ribonucleoprotein particle (U1A) interacting with its RNA target U1 hairpin II (U1hpII) provided experimental evidence for a ‘lure and lock’ model of binding. The fi...

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Detalles Bibliográficos
Autores principales: Law, Michael J., Lee, Diane S., Lee, Charlene S., Anglim, Paul P., Haworth, Ian S., Laird-Offringa, Ite A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737524/
https://www.ncbi.nlm.nih.gov/pubmed/23703211
http://dx.doi.org/10.1093/nar/gkt326