UGA codon position-dependent incorporation of selenocysteine into mammalian selenoproteins

It is thought that the SelenoCysteine Insertion Sequence (SECIS) element and UGA codon are sufficient for selenocysteine (Sec) insertion. However, we found that UGA supported Sec insertion only at its natural position or in its close proximity in mammalian thioredoxin reductase 1 (TR1). In contrast,...

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Detalles Bibliográficos
Autores principales: Turanov, Anton A., Lobanov, Alexei V., Hatfield, Dolph L., Gladyshev, Vadim N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737529/
https://www.ncbi.nlm.nih.gov/pubmed/23716634
http://dx.doi.org/10.1093/nar/gkt409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737529/
https://www.ncbi.nlm.nih.gov/pubmed/23716634
http://dx.doi.org/10.1093/nar/gkt409

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