Uridylation prevents 3′ trimming of oligoadenylated mRNAs

Degradation of mRNAs is usually initiated by deadenylation, the shortening of long poly(A) tails to oligo(A) tails of 12–15 As. Deadenylation leads to decapping and to subsequent 5′ to 3′ degradation by XRN proteins, or alternatively 3′ to 5′ degradation by the exosome. Decapping can also be induced...

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Detalles Bibliográficos
Autores principales: Sement, François Michaël, Ferrier, Emilie, Zuber, Hélène, Merret, Rémy, Alioua, Malek, Deragon, Jean-Marc, Bousquet-Antonelli, Cécile, Lange, Heike, Gagliardi, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737552/
https://www.ncbi.nlm.nih.gov/pubmed/23748567
http://dx.doi.org/10.1093/nar/gkt465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737552/
https://www.ncbi.nlm.nih.gov/pubmed/23748567
http://dx.doi.org/10.1093/nar/gkt465

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