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Cooperative Unfolding of Compact Conformations of the Intrinsically Disordered Protein Osteopontin
[Image: see text] Intrinsically disordered proteins (IDPs) constitute a class of biologically active proteins that lack defined tertiary and often secondary structure. The IDP Osteopontin (OPN), a cytokine involved in metastasis of several types of cancer, is shown to simultaneously sample extended,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737600/ https://www.ncbi.nlm.nih.gov/pubmed/23848319 http://dx.doi.org/10.1021/bi400502c |