GSK-3 and lysosomes meet in Alzheimer’s disease

Aberrant regulation of glycogen synthase kinase-3 (GSK-3) is implicated in Alzheimer’s disease (AD), but the mechanisms involved remain elusive. Our recent study shows that GSK-3 impairs lysosomal acidification and that inhibition of GSK-3 re-acidified lysosomes in brains of AD mice. This effect was...

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Detalles Bibliográficos
Autores principales: Avrahami, Limor, Eldar-Finkelman, Hagit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737746/
https://www.ncbi.nlm.nih.gov/pubmed/23940827
http://dx.doi.org/10.4161/cib.25179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737746/
https://www.ncbi.nlm.nih.gov/pubmed/23940827
http://dx.doi.org/10.4161/cib.25179

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