An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence

ATR activation is dependent on temporal and spatial interactions with partner proteins. In the budding yeast model, three proteins – Dpb11(TopBP1), Ddc1(Rad9) and Dna2 - all interact with and activate Mec1(ATR). Each contains an ATR activation domain (ADD) that interacts directly with the Mec1(ATR):...

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Detalles Bibliográficos
Autores principales: Zhou, Zhong-Wei, Liu, Cong, Li, Tang-Liang, Bruhn, Christopher, Krueger, Anja, Min, WooKee, Wang, Zhao-Qi, Carr, Antony M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738440/
https://www.ncbi.nlm.nih.gov/pubmed/23950734
http://dx.doi.org/10.1371/journal.pgen.1003702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738440/
https://www.ncbi.nlm.nih.gov/pubmed/23950734
http://dx.doi.org/10.1371/journal.pgen.1003702

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