Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster

Autophagy, a lysosomal self-degradation and recycling pathway, plays dual roles in tumorigenesis. Autophagy deficiency predisposes to cancer, at least in part, through accumulation of the selective autophagy cargo p62, leading to activation of antioxidant responses and tumor formation. While cell gr...

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Detalles Bibliográficos
Autores principales: Nagy, Péter, Varga, Ágnes, Pircs, Karolina, Hegedűs, Krisztina, Juhász, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738540/
https://www.ncbi.nlm.nih.gov/pubmed/23950728
http://dx.doi.org/10.1371/journal.pgen.1003664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738540/
https://www.ncbi.nlm.nih.gov/pubmed/23950728
http://dx.doi.org/10.1371/journal.pgen.1003664

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