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Binding of Dopamine to Alpha-Synuclein is Mediated by Specific Conformational States

Parkinson’s disease is the second most common neurodegenerative disorder, in which both alpha-synuclein (α-syn) and dopamine (DA) have a critical role. α-Syn is known to be natively unstructured in equilibrium with subpopulations of more compact structures. It is these compact structures that are th...

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Detalles Bibliográficos
Autores principales: Illes-Toth, Eva, Dalton, Caroline F., Smith, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738842/
https://www.ncbi.nlm.nih.gov/pubmed/23817832
http://dx.doi.org/10.1007/s13361-013-0676-z