PKCθ Regulates T-Cell Leukemia-Initiating Activity via Reactive Oxygen Species

Reactive oxygen species (ROS), a by-product of cellular metabolism, damage intracellular macromolecules and, in excess, can promote normal hematopoietic stem cell differentiation and exhaustion(1–3). However, mechanisms that regulate ROS levels in leukemia-initiating cells (LICs) and the biological...

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Detalles Bibliográficos
Autores principales: Giambra, Vincenzo, Jenkins, Christopher R., Wang, Hongfang, Lam, Sonya H., Shevchuk, Olena O., Nemirovsky, Oksana, Wai, Carol, Gusscott, Sam, Chiang, Mark Y., Aster, Jon C., Humphries, R. Keith, Eaves, Connie, Weng, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738873/
https://www.ncbi.nlm.nih.gov/pubmed/23086478
http://dx.doi.org/10.1038/nm.2960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738873/
https://www.ncbi.nlm.nih.gov/pubmed/23086478
http://dx.doi.org/10.1038/nm.2960

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