The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis

The brain microenvironment promotes metastasis through mechanisms that remain elusive. Co-culture of lung cancer cells with astrocytes - the most abundant cell type within the metastatic brain niche – lead to downregulation of miRNA-768-3p which drives K-ras expression and key signaling pathways, en...

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Detalles Bibliográficos
Autores principales: Subramani, Arasukumar, Alsidawi, Samer, Jagannathan, Sajjeev, Sumita, Kazutaka, Sasaki, Atsuo T., Aronow, Bruce, Warnick, Ronald E., Lawler, Sean, Driscoll, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738968/
https://www.ncbi.nlm.nih.gov/pubmed/23928793
http://dx.doi.org/10.1038/srep02392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738968/
https://www.ncbi.nlm.nih.gov/pubmed/23928793
http://dx.doi.org/10.1038/srep02392

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