Sonic Hedgehog-Induced Histone Deacetylase Activation Is Required for Cerebellar Granule Precursor Hyperplasia in Medulloblastoma

Medulloblastoma, the most common pediatric brain tumor, is thought to arise from deregulated proliferation of cerebellar granule precursor (CGP) cells. Sonic hedgehog (Shh) is the primary mitogen that regulates proliferation of CGP cells during the early stages of postnatal cerebellum development. A...

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Detalles Bibliográficos
Autores principales: Lee, Seung Joon, Lindsey, Stephan, Graves, Bruce, Yoo, Soonmoon, Olson, James M., Langhans, Sigrid A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739791/
https://www.ncbi.nlm.nih.gov/pubmed/23951168
http://dx.doi.org/10.1371/journal.pone.0071455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739791/
https://www.ncbi.nlm.nih.gov/pubmed/23951168
http://dx.doi.org/10.1371/journal.pone.0071455

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