Structural Guided Scaffold Phage Display Libraries as a Source of Bio-Therapeutics

We have developed a structurally-guided scaffold phage display strategy for identification of ligand mimetic bio-therapeutics. As a proof of concept we used the ligand of integrin αvβ6, a tumour cell surface receptor and a major new target for imaging and therapy of many types of solid cancer. NMR s...

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Detalles Bibliográficos
Autores principales: Man, Y. K. Stella, DiCara, Danielle, Chan, Nicole, Vessillier, Sandrine, Mather, Stephen J., Rowe, Michelle L., Howard, Mark J., Marshall, John F., Nissim, Ahuva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739823/
https://www.ncbi.nlm.nih.gov/pubmed/23950939
http://dx.doi.org/10.1371/journal.pone.0070452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739823/
https://www.ncbi.nlm.nih.gov/pubmed/23950939
http://dx.doi.org/10.1371/journal.pone.0070452

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