Ataxin-2 Modulates the Levels of Grb2 and Src but Not Ras Signaling

Ataxin-2 (ATXN2) is implicated mainly in mRNA processing. Some ATXN2 associates with receptor tyrosine kinases (RTK), inhibiting their endocytic internalization through interaction of proline-rich domains (PRD) in ATXN2 with SH3 motifs in Src. Gain of function of ATXN2 leads to neuronal atrophy in t...

Descripción completa

Detalles Bibliográficos
Autores principales: Drost, Jessica, Nonis, David, Eich, Florian, Leske, Oliver, Damrath, Ewa, Brunt, Ewout R., Lastres-Becker, Isabel, Heumann, Rolf, Nowock, Joachim, Auburger, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739869/
https://www.ncbi.nlm.nih.gov/pubmed/23335000
http://dx.doi.org/10.1007/s12031-012-9949-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739869/
https://www.ncbi.nlm.nih.gov/pubmed/23335000
http://dx.doi.org/10.1007/s12031-012-9949-4

Ejemplares similares