Cargando…

Activated Human T Cells Express Alternative mRNA Transcripts Encoding a Secreted Form of RANKL

Receptor activator of nuclear factor-kappaB -ligand (RANKL), encoded by the gene TNFSF11, is required for osteoclastogenesis, and its expression is upregulated in pathologic bone loss. Transcript variants of TNFSF11 mRNA have been described that encode a membrane-bound and a putative secreted form o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walsh, NC, Alexander, KA, Manning, CA, Karmakar, S, Wang, JF, Weyand, CM, Pettit, AR, Gravallese, EM
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740552/ https://www.ncbi.nlm.nih.gov/pubmed/23698708 http://dx.doi.org/10.1038/gene.2013.29

Ejemplares similares

Circulating RANKL is inversely related to RANKL mRNA levels in bone in osteoarthritic males
por: Findlay, David, et al.
Publicado: (2008)

Adverse effects of rheumatoid arthritis on bone remodeling
por: Goldring, SR, et al.
Publicado: (2004)

Different forms of microtubule-associated protein 2 are encoded by separate mRNA transcripts
Publicado: (1988)

Inhibition of RANKL-Induced Osteoclastogenesis by Novel Mutant RANKL
por: Jang, Yuria, et al.
Publicado: (2021)

A widespread alternate form of cap-dependent mRNA translation initiation
por: de la Parra, Columba, et al.
Publicado: (2018)

Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond
por: Walsh, Matthew C., et al.
Publicado: (2014)

Cervical (pre)neoplastic microenvironment promotes the emergence of tolerogenic dendritic cells via RANKL secretion
por: Demoulin, Stéphanie A, et al.
Publicado: (2015)

Serum RANKL, osteoprotegerin (OPG), and RANKL/OPG ratio in nephrotic children
por: Wasilewska, Anna, et al.
Publicado: (2010)

From discovery of RANKL to clinical application of anti-human RANKL antibody
por: Yasuda, Hisataka, et al.
Publicado: (2012)

RANKL Expression in Periodontal Disease: Where Does RANKL Come from?
por: Chen, Bin, et al.
Publicado: (2014)

Expression and Presence of OPG and RANKL mRNA and Protein in Human Periodontal Ligament with Orthodontic Force
por: Otero, Liliana, et al.
Publicado: (2016)

Localization during development of alternatively spliced forms of cytotactin mRNA by in situ hybridization
Publicado: (1990)

Alternative Forms of Y-Box Binding Protein 1 and YB-1 mRNA
por: Lyabin, Dmitry N., et al.
Publicado: (2014)

Targeting RANKL in metastasis
por: Dougall, William C, et al.
Publicado: (2014)

The Soluble Form of the EIAV Receptor Encoded by an Alternative Splicing Variant Inhibits EIAV Infection of Target Cells
por: Lin, Yue-Zhi, et al.
Publicado: (2013)

Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis
por: Yeo, Lorraine, et al.
Publicado: (2011)

A New Splice Variant of the Major Subunit of Human Asialoglycoprotein Receptor Encodes a Secreted Form in Hepatocytes
por: Liu, Jia, et al.
Publicado: (2010)

Polymorphisms within the RANK and RANKL Encoding Genes in Patients with Rheumatoid Arthritis: Association with Disease Progression and Effectiveness of the Biological Treatment
por: Wielińska, Joanna, et al.
Publicado: (2020)

The Secrets of Alternative Autophagy
por: Urbańska, Kaja, et al.
Publicado: (2021)

Histopathology of Bone Erosions in Rheumatoid Arthritis
por: Gravallese, Ellen, et al.
Publicado: (2000)

Effects of high frequency loading on RANKL and OPG mRNA expression in ST-2 murine stromal cells
por: Kim, Chi Hyun, et al.
Publicado: (2009)

Biology of RANK, RANKL, and osteoprotegerin
por: Boyce, Brendan F, et al.
Publicado: (2007)

Role of RANKL inhibition in osteoporosis
por: McClung, Michael
Publicado: (2007)

RANK–RANKL signalling in cancer
por: Renema, Nathalie, et al.
Publicado: (2016)

Attenuated RANKL-induced cytotoxicity by Portulaca oleracea ethanol extract enhances RANKL-mediated osteoclastogenesis
por: Erkhembaatar, Munkhsoyol, et al.
Publicado: (2015)

Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
por: Golec, Ewelina, et al.
Publicado: (2022)

Mesenchymal Stromal Cell‐Seeded Biomimetic Scaffolds as a Factory of Soluble RANKL in Rankl‐Deficient Osteopetrosis
por: Menale, Ciro, et al.
Publicado: (2018)

The Role of the RANKL/RANK Axis in the Prevention and Treatment of Breast Cancer with Immune Checkpoint Inhibitors and Anti-RANKL
por: Simatou, Aristofania, et al.
Publicado: (2020)

RANKL immunisation inhibits prostate cancer metastasis by modulating EMT through a RANKL-dependent pathway
por: Park, Mineon, et al.
Publicado: (2021)

Two unusual forms of human immunoglobulin E encoded by alternative RNA splicing of epsilon heavy chain membrane exons
Publicado: (1992)

DDD pacemaker for severe heart failure-alternate to CRT
por: Krishnamani, N.C.
Publicado: (2017)

Clinical development of anti-RANKL therapy
por: Schwarz, Edward M, et al.
Publicado: (2007)

Mitf Induction by RANKL Is Critical for Osteoclastogenesis
por: Lu, Ssu-Yi, et al.
Publicado: (2010)

Emerging Functions of RANKL in Lymphoid Tissues
por: Mueller, Christopher G., et al.
Publicado: (2012)

RANK/RANKL expression in prostate cancer
por: Ohtaka, Mari, et al.
Publicado: (2016)

The Roadmap of RANKL/RANK Pathway in Cancer
por: Casimiro, Sandra, et al.
Publicado: (2021)

RANKL regulates male reproductive function
por: Blomberg Jensen, Martin, et al.
Publicado: (2021)

Genome-Wide Identification of Alternative Splice Forms Down-Regulated by Nonsense-Mediated mRNA Decay in Drosophila
por: Hansen, Kasper Daniel, et al.
Publicado: (2009)

Immunogenicity and protective efficacy of SARS-CoV-2 mRNA vaccine encoding secreted non-stabilized spike in female mice
por: Prompetchara, Eakachai, et al.
Publicado: (2023)

Auranofin Inhibits RANKL-Induced Osteoclastogenesis by Suppressing Inhibitors of κB Kinase and Inflammasome-Mediated Interleukin-1β Secretion
por: Kim, Hyun Young, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_d156aoipm2g13vf4kj8a6for05