Identification of ROCK1 kinase as a critical regulator of Beclin1 mediated autophagy during metabolic stress

The Ser/Thr Rho kinase 1 (ROCK1) is known to play major roles in a wide range of cellular activities, including those involved in tumor metastasis and apoptosis. Here we identify an indispensable function of ROCK1 in metabolic stress-induced autophagy. Applying a proteomics approach, we characterize...

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Detalles Bibliográficos
Autores principales: Gurkar, Aditi U., Chu, Kiki, Raj, Lakshmi, Bouley, Richard, Lee, Seung-Hwan, Kim, Young-Bum, Dunn, Sandra E., Mandinova, Anna, Lee, Sam W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740589/
https://www.ncbi.nlm.nih.gov/pubmed/23877263
http://dx.doi.org/10.1038/ncomms3189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740589/
https://www.ncbi.nlm.nih.gov/pubmed/23877263
http://dx.doi.org/10.1038/ncomms3189

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