Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition

Katsumadain A, a naturally occurring influenza virus neuraminidase (NA) inhibitor, was synthesized by using a bioinspired, organocatalytic enantioselective 1,4-conjugate addition of styryl-2-pyranone with cinnamaldehyde, followed by a tandem Horner–Wadsworth–Emmons/oxa Michael addition.

Detalles Bibliográficos
Autores principales: Wang, Yongguang, Bao, Ruiyang, Huang, Shengdian, Tang, Yefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740603/
https://www.ncbi.nlm.nih.gov/pubmed/23946860
http://dx.doi.org/10.3762/bjoc.9.182
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author Wang, Yongguang
Bao, Ruiyang
Huang, Shengdian
Tang, Yefeng
author_facet Wang, Yongguang
Bao, Ruiyang
Huang, Shengdian
Tang, Yefeng
author_sort Wang, Yongguang
collection PubMed
description Katsumadain A, a naturally occurring influenza virus neuraminidase (NA) inhibitor, was synthesized by using a bioinspired, organocatalytic enantioselective 1,4-conjugate addition of styryl-2-pyranone with cinnamaldehyde, followed by a tandem Horner–Wadsworth–Emmons/oxa Michael addition.
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spelling pubmed-37406032013-08-14 Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition Wang, Yongguang Bao, Ruiyang Huang, Shengdian Tang, Yefeng Beilstein J Org Chem Letter Katsumadain A, a naturally occurring influenza virus neuraminidase (NA) inhibitor, was synthesized by using a bioinspired, organocatalytic enantioselective 1,4-conjugate addition of styryl-2-pyranone with cinnamaldehyde, followed by a tandem Horner–Wadsworth–Emmons/oxa Michael addition. Beilstein-Institut 2013-08-06 /pmc/articles/PMC3740603/ /pubmed/23946860 http://dx.doi.org/10.3762/bjoc.9.182 Text en Copyright © 2013, Wang et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Wang, Yongguang
Bao, Ruiyang
Huang, Shengdian
Tang, Yefeng
Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition
title Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition
title_full Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition
title_fullStr Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition
title_full_unstemmed Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition
title_short Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition
title_sort bioinspired total synthesis of katsumadain a by organocatalytic enantioselective 1,4-conjugate addition
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740603/
https://www.ncbi.nlm.nih.gov/pubmed/23946860
http://dx.doi.org/10.3762/bjoc.9.182
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