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Functional Polymorphisms in FAS/FASL System Increase the Risk of Neuroblastoma in Chinese Population

The FAS and FASL system plays a substantial role in apoptosis and immune escape of cells. Three polymorphisms located in the promoter regions of FAS (-1377G/A and -670A/G) and FASL (-844T/C) have been shown to alter the transcriptional activity of the genes, respectively. This study was conducted to...

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Autores principales: Han, Wei, Zhou, Yuling, Zhong, Rong, Wu, Chen, Song, Ranran, Liu, Li, Zou, Li, Qiao, Yan, Zhai, Kan, Chang, Jiang, Huang, Liming, Lu, Xuzai, Lou, Jiao, Yu, Dianke, Tan, Wen, Zhang, Jinzhe, Wang, Huanmin, Miao, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741122/
https://www.ncbi.nlm.nih.gov/pubmed/23951214
http://dx.doi.org/10.1371/journal.pone.0071656
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author Han, Wei
Zhou, Yuling
Zhong, Rong
Wu, Chen
Song, Ranran
Liu, Li
Zou, Li
Qiao, Yan
Zhai, Kan
Chang, Jiang
Huang, Liming
Liu, Li
Lu, Xuzai
Lou, Jiao
Yu, Dianke
Tan, Wen
Zhang, Jinzhe
Wang, Huanmin
Miao, Xiaoping
author_facet Han, Wei
Zhou, Yuling
Zhong, Rong
Wu, Chen
Song, Ranran
Liu, Li
Zou, Li
Qiao, Yan
Zhai, Kan
Chang, Jiang
Huang, Liming
Liu, Li
Lu, Xuzai
Lou, Jiao
Yu, Dianke
Tan, Wen
Zhang, Jinzhe
Wang, Huanmin
Miao, Xiaoping
author_sort Han, Wei
collection PubMed
description The FAS and FASL system plays a substantial role in apoptosis and immune escape of cells. Three polymorphisms located in the promoter regions of FAS (-1377G/A and -670A/G) and FASL (-844T/C) have been shown to alter the transcriptional activity of the genes, respectively. This study was conducted to evaluate the effects of these polymorphisms on the susceptibility of neuroblastoma in the Chinese population. A total of 203 patients with neuroblastoma and 411 controls were recruited in this case-control study. Polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) was applied for genotyping. Unconditional logistic regression was used to estimate cancer risk by calculating odds ratios (ORs) and their 95% confidence intervals (95% CIs). It was observed that significantly increased risks of neuroblastoma associated with FAS -1377G/A and FASL -844T/C polymorphisms, with ORs equal to 1.55 (95% CI, 1.10–2.20) for FAS -1377 A allele and 2.90 (95% CI, 2.04–4.12) for FASL -844CC genotype carriers compared with non-carriers, respectively. However, no association was found between the polymorphisms of FAS -670A/G and risk of neuroblastoma. In addition, the cumulative effect of FAS and FASL polymorphisms on risk of neuroblastoma was observed (P for trend = 2.502×10(−10)), with OR for the carriers of both FAS -1377A allele and FASL -844CC genotypes equaled to 3.95 (95% CI, 2.40–6.51). This work reveals that polymorphisms of FAS -1377G/A and FASL -844T/C but not FAS -670A/G are associated with risk of neuroblastoma in Chinese. These findings support the hypothesis that genetic polymorphism in FAS/FASL death system may influence individual susceptibility to neuroblastoma.
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spelling pubmed-37411222013-08-15 Functional Polymorphisms in FAS/FASL System Increase the Risk of Neuroblastoma in Chinese Population Han, Wei Zhou, Yuling Zhong, Rong Wu, Chen Song, Ranran Liu, Li Zou, Li Qiao, Yan Zhai, Kan Chang, Jiang Huang, Liming Liu, Li Lu, Xuzai Lou, Jiao Yu, Dianke Tan, Wen Zhang, Jinzhe Wang, Huanmin Miao, Xiaoping PLoS One Research Article The FAS and FASL system plays a substantial role in apoptosis and immune escape of cells. Three polymorphisms located in the promoter regions of FAS (-1377G/A and -670A/G) and FASL (-844T/C) have been shown to alter the transcriptional activity of the genes, respectively. This study was conducted to evaluate the effects of these polymorphisms on the susceptibility of neuroblastoma in the Chinese population. A total of 203 patients with neuroblastoma and 411 controls were recruited in this case-control study. Polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) was applied for genotyping. Unconditional logistic regression was used to estimate cancer risk by calculating odds ratios (ORs) and their 95% confidence intervals (95% CIs). It was observed that significantly increased risks of neuroblastoma associated with FAS -1377G/A and FASL -844T/C polymorphisms, with ORs equal to 1.55 (95% CI, 1.10–2.20) for FAS -1377 A allele and 2.90 (95% CI, 2.04–4.12) for FASL -844CC genotype carriers compared with non-carriers, respectively. However, no association was found between the polymorphisms of FAS -670A/G and risk of neuroblastoma. In addition, the cumulative effect of FAS and FASL polymorphisms on risk of neuroblastoma was observed (P for trend = 2.502×10(−10)), with OR for the carriers of both FAS -1377A allele and FASL -844CC genotypes equaled to 3.95 (95% CI, 2.40–6.51). This work reveals that polymorphisms of FAS -1377G/A and FASL -844T/C but not FAS -670A/G are associated with risk of neuroblastoma in Chinese. These findings support the hypothesis that genetic polymorphism in FAS/FASL death system may influence individual susceptibility to neuroblastoma. Public Library of Science 2013-08-12 /pmc/articles/PMC3741122/ /pubmed/23951214 http://dx.doi.org/10.1371/journal.pone.0071656 Text en © 2013 Han et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Han, Wei
Zhou, Yuling
Zhong, Rong
Wu, Chen
Song, Ranran
Liu, Li
Zou, Li
Qiao, Yan
Zhai, Kan
Chang, Jiang
Huang, Liming
Liu, Li
Lu, Xuzai
Lou, Jiao
Yu, Dianke
Tan, Wen
Zhang, Jinzhe
Wang, Huanmin
Miao, Xiaoping
Functional Polymorphisms in FAS/FASL System Increase the Risk of Neuroblastoma in Chinese Population
title Functional Polymorphisms in FAS/FASL System Increase the Risk of Neuroblastoma in Chinese Population
title_full Functional Polymorphisms in FAS/FASL System Increase the Risk of Neuroblastoma in Chinese Population
title_fullStr Functional Polymorphisms in FAS/FASL System Increase the Risk of Neuroblastoma in Chinese Population
title_full_unstemmed Functional Polymorphisms in FAS/FASL System Increase the Risk of Neuroblastoma in Chinese Population
title_short Functional Polymorphisms in FAS/FASL System Increase the Risk of Neuroblastoma in Chinese Population
title_sort functional polymorphisms in fas/fasl system increase the risk of neuroblastoma in chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741122/
https://www.ncbi.nlm.nih.gov/pubmed/23951214
http://dx.doi.org/10.1371/journal.pone.0071656
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