Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNFα Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells

OBJECTIVE: Mitochondrial transcription factor A (TFAM) is normally bound to and remains associated with mitochondrial DNA (mtDNA) when released from damaged cells. We hypothesized that TFAM, bound to mtDNA (or equivalent CpG-enriched DNA), amplifies TNFα release from TLR9-expressing plasmacytoid den...

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Detalles Bibliográficos
Autores principales: Julian, Mark W., Shao, Guohong, VanGundy, Zachary C., Papenfuss, Tracey L., Crouser, Elliott D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741150/
https://www.ncbi.nlm.nih.gov/pubmed/23951313
http://dx.doi.org/10.1371/journal.pone.0072354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741150/
https://www.ncbi.nlm.nih.gov/pubmed/23951313
http://dx.doi.org/10.1371/journal.pone.0072354

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