Oxaliplatin and Its Enantiomer Induce Different Condensation Dynamics of Single DNA Molecules

The interactions of DNA with oxaliplatin (Pt(R,R-DACH)) or its enantiomer (Pt(S,S-DACH)) were investigated using magnetic tweezers and atomic force microscope. In the process of DNA condensation induced by Pt-DACH, only diadducts and micro-loops are formed at low Pt-DACH concentrations, while at hig...

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Detalles Bibliográficos
Autores principales: Zhang, Hong-Yan, Liu, Yu-Ru, Ji, Chao, Li, Wei, Dou, Shuo-Xing, Xie, Ping, Wang, Wei-Chi, Zhang, Ling-Yun, Wang, Peng-Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741182/
https://www.ncbi.nlm.nih.gov/pubmed/23951187
http://dx.doi.org/10.1371/journal.pone.0071556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741182/
https://www.ncbi.nlm.nih.gov/pubmed/23951187
http://dx.doi.org/10.1371/journal.pone.0071556

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