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CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Has Anti-Aging Effects That Protect Articular Cartilage from Age-Related Degenerative Changes

To examine the role of connective tissue growth factor CCN2/CTGF (CCN2) in the maintenance of the articular cartilaginous phenotype, we analyzed knee joints from aging transgenic mice (TG) overexpressing CCN2 driven by the Col2a1 promoter. Knee joints from 3-, 14-, 40-, and 60-day-old and 5-, 12-, 1...

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Detalles Bibliográficos
Autores principales:	Itoh, Shinsuke, Hattori, Takako, Tomita, Nao, Aoyama, Eriko, Yutani, Yasutaka, Yamashiro, Takashi, Takigawa, Masaharu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741357/ https://www.ncbi.nlm.nih.gov/pubmed/23951098 http://dx.doi.org/10.1371/journal.pone.0071156

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