Cargando…

NS3 Protease from Hepatitis C Virus: Biophysical Studies on an Intrinsically Disordered Protein Domain

The nonstructural protein 3 (NS3) from the hepatitis C virus (HCV) is responsible for processing the non-structural region of the viral precursor polyprotein in infected hepatic cells. NS3 protease activity, located at the N-terminal domain, is a zinc-dependent serine protease. A zinc ion, required...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vega, Sonia, Neira, Jose L., Marcuello, Carlos, Lostao, Anabel, Abian, Olga, Velazquez-Campoy, Adrian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742187/ https://www.ncbi.nlm.nih.gov/pubmed/23803659 http://dx.doi.org/10.3390/ijms140713282

Ejemplares similares

Allosteric Inhibitors of the NS3 Protease from the Hepatitis C Virus
por: Abian, Olga, et al.
Publicado: (2013)

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma
por: Neira, José L., et al.
Publicado: (2017)

Targeting intrinsically disordered proteins involved in cancer
por: Santofimia-Castaño, Patricia, et al.
Publicado: (2019)

The Paralogue of the Intrinsically Disordered Nuclear Protein 1 Has a Nuclear Localization Sequence that Binds to Human Importin α3
por: Neira, José L., et al.
Publicado: (2020)

Stabilization Effect of Intrinsically Disordered Regions on Multidomain Proteins: The Case of the Methyl-CpG Protein 2, MeCP2
por: Ortega-Alarcon, David, et al.
Publicado: (2021)

A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin
por: Neira, José L., et al.
Publicado: (2020)

Conformational Stability of the N-Terminal Region of MDM2
por: Rizzuti, Bruno, et al.
Publicado: (2023)

The FAD synthetase from the human pathogen Streptococcus pneumoniae: a bifunctional enzyme exhibiting activity-dependent redox requirements
por: Sebastián, María, et al.
Publicado: (2017)

Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function
por: Rizzuti, Bruno, et al.
Publicado: (2021)

Molecular Recognition of Proteins through Quantitative Force Maps at Single Molecule Level
por: Marcuello, Carlos, et al.
Publicado: (2022)

The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site
por: Claveria-Gimeno, Rafael, et al.
Publicado: (2017)

Deconvolution Analysis for Classifying Gastric Adenocarcinoma Patients Based on Differential Scanning Calorimetry Serum Thermograms
por: Vega, Sonia, et al.
Publicado: (2015)

Beyond a platform protein for the degradosome assembly: The Apoptosis-Inducing Factor as an efficient nuclease involved in chromatinolysis
por: Novo, Nerea, et al.
Publicado: (2022)

Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs
por: Rizzuti, Bruno, et al.
Publicado: (2021)

Identification of NS2 determinants stimulating intrinsic HCV NS2 protease activity
por: Isken, Olaf, et al.
Publicado: (2022)

Atomic Force Microscopy to Elicit Conformational Transitions of Ferredoxin-Dependent Flavin Thioredoxin Reductases
por: Marcuello, Carlos, et al.
Publicado: (2021)

In Vitro Antiviral Activity of Tyrosinase from Mushroom Agaricus bisporus against Hepatitis C Virus
por: Lopez-Tejedor, David, et al.
Publicado: (2021)

Human Enzyme PADI4 Binds to the Nuclear Carrier Importin α3
por: Neira, José L., et al.
Publicado: (2022)

Molecular Context-Dependent Effects Induced by Rett Syndrome-Associated Mutations in MeCP2
por: Ortega-Alarcon, David, et al.
Publicado: (2020)

Autochthonous Peruvian Natural Plants as Potential SARS-CoV-2 M(pro) Main Protease Inhibitors
por: Peralta-Moreno, Maria Nuria, et al.
Publicado: (2023)

Rescuing compound bioactivity in a secondary cell-based screening by using γ-cyclodextrin as a molecular carrier
por: Claveria-Gimeno, Rafael, et al.
Publicado: (2015)

Thermal Liquid Biopsy (TLB): A Predictive Score Derived from Serum Thermograms as a Clinical Tool for Screening Lung Cancer Patients
por: Rodrigo, Alberto, et al.
Publicado: (2019)

Fluorescence Liquid Biopsy for Cancer Detection Is Improved by Using Cationic Dendronized Hyperbranched Polymer
por: Morcuende-Ventura, Violeta, et al.
Publicado: (2021)

Nanomechanical Study of Enzyme: Coenzyme Complexes: Bipartite Sites in Plastidic Ferredoxin-NADP(+) Reductase for the Interaction with NADP(+)
por: Pérez-Domínguez, Sandra, et al.
Publicado: (2022)

Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening
por: Abian, Olga, et al.
Publicado: (2020)

Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors
por: Felix, Jan, et al.
Publicado: (2019)

Discovery of Diverse Natural Products as Inhibitors of SARS-CoV-2 M(pro) Protease through Virtual Screening
por: Rubio-Martínez, Jaime, et al.
Publicado: (2021)

Experimental validation of in silico target predictions on synergistic protein targets
por: Cortes-Ciriano, Isidro, et al.
Publicado: (2013)

Molecular models of NS3 protease variants of the Hepatitis C virus
por: da Silveira, Nelson JF, et al.
Publicado: (2005)

Biophysical Properties of Intrinsically Disordered p130Cas Substrate Domain — Implication in Mechanosensing
por: Hotta, Kinya, et al.
Publicado: (2014)

Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural Compounds
por: Rizzuti, Bruno, et al.
Publicado: (2021)

Repositioning small molecule drugs as allosteric inhibitors of the BFT‐3 toxin from enterotoxigenic Bacteroides fragilis
por: Jimenez‐Alesanco, Ana, et al.
Publicado: (2022)

Bowel Preparation for Colonoscopy Changes Serum Composition as Detected by Thermal Liquid Biopsy and Fluorescence Spectroscopy
por: Hermoso-Durán, Sonia, et al.
Publicado: (2023)

Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction
por: Verma, Apoorva, et al.
Publicado: (2018)

Hepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 Helicase
por: Beran, Rudolf K. F., et al.
Publicado: (2008)

Thermal Liquid Biopsy (TLB) Focused on Benign and Premalignant Pancreatic Cyst Diagnosis
por: Hermoso-Durán, Sonia, et al.
Publicado: (2020)

Enzyme/Nanocopper Hybrid Nanozymes: Modulating Enzyme-like Activity by the Protein Structure for Biosensing and Tumor Catalytic Therapy
por: Losada-Garcia, Noelia, et al.
Publicado: (2021)

NS2 proteases from hepatitis C virus and related hepaciviruses share composite active sites and previously unrecognized intrinsic proteolytic activities
por: Boukadida, Célia, et al.
Publicado: (2018)

New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4
por: Araujo‐Abad, Salomé, et al.
Publicado: (2023)

Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors
por: Zeminian, Luciana Bonome, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_12sqcgeelhpohjubfpmg2o2cqp