Membrane Binding and Insertion of a pHLIP Peptide Studied by All-Atom Molecular Dynamics Simulations

Recent experiments in function mechanism study reported that a pH low-insertion peptide (pHLIP) can insert into a zwitterionic palmitoyloleoylphosphatidylcholine (POPC) lipid bilayer at acidic pH while binding to the bilayer surface at basic pH. However, the atomic details of the pH-dependent intera...

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Detalles Bibliográficos
Autores principales: Deng, Yonghua, Qian, Zhenyu, Luo, Yin, Zhang, Yun, Mu, Yuguang, Wei, Guanghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742258/
https://www.ncbi.nlm.nih.gov/pubmed/23857053
http://dx.doi.org/10.3390/ijms140714532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742258/
https://www.ncbi.nlm.nih.gov/pubmed/23857053
http://dx.doi.org/10.3390/ijms140714532

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