Cargando…

MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4

MDM2 Binding Protein (MTBP) has been implicated in cancer progression. Here we demonstrate one mechanism by which MTBP inhibits cancer metastasis. Overexpression of MTBP in human osteosarcoma cell lines lacking wild-type p53 did not alter primary tumor growth in mice but significantly inhibited meta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Agarwal, Neeraj, Adhikari, Amit S., Iyer, Swathi V., Hekmatdoost, Kevon, Welch, Danny R., Iwakuma, Tomoo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742333/ https://www.ncbi.nlm.nih.gov/pubmed/22370640 http://dx.doi.org/10.1038/onc.2012.69

Ejemplares similares

MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma
por: Ranjan, Atul, et al.
Publicado: (2018)

Characterization of an Mtbp Hypomorphic Allele in a Diethylnitrosamine-Induced Liver Carcinogenesis Model
por: Ranjan, Atul, et al.
Publicado: (2023)

A deficiency in Mdm2 binding protein (MTBP) inhibits Myc-induced B cell proliferation and lymphomagenesis
por: Odvody, Jessica, et al.
Publicado: (2010)

A novel link between the HER2-Akt and MDM2-p53 pathways via CSN6
por: Iyer, Swathi V., et al.
Publicado: (2012)

Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma
por: Kundu, Anup K., et al.
Publicado: (2017)

Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities
por: Iyer, Swathi V., et al.
Publicado: (2015)

The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation
por: Volpi, Ilaria, et al.
Publicado: (2021)

MTBP promoted the proliferation, migration and invasion of colon cancer cells by activating the expression of ZEB2
por: Shayimu, Paerhati, et al.
Publicado: (2021)

PTENε suppresses tumor metastasis through regulation of filopodia formation
por: Zhang, Qiaoling, et al.
Publicado: (2021)

MTBP phosphorylation controls DNA replication origin firing
por: Ferreira, Pedro, et al.
Publicado: (2021)

The Role of MTBP as a Replication Origin Firing Factor
por: Zaffar, Eman, et al.
Publicado: (2022)

Formation of filopodia-like bundles in vitro from a dendritic network
por: Vignjevic, Danijela, et al.
Publicado: (2003)

MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and Aging
por: Grieb, Brian C., et al.
Publicado: (2022)

Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome‐wide shRNA screen
por: Kurahara, Hiroshi, et al.
Publicado: (2016)

MTBP promotes migration and invasion by regulation of ZEB2-mediated epithelial–mesenchymal transition in lung cancer cells
por: Pan, Bo, et al.
Publicado: (2018)

GPR124 facilitates pericyte polarization and migration by regulating the formation of filopodia during ischemic injury
por: Chen, Dan-Yang, et al.
Publicado: (2019)

MTBP promotes migration and invasion by regulation of ZEB2-mediated epithelial–mesenchymal transition in lung cancer cells [Corrigendum]
Publicado: (2018)

MTBP regulates cell survival and therapeutic sensitivity in TP53 wildtype glioblastomas
por: Song, Yifu, et al.
Publicado: (2019)

The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition
por: Zonderland, Gijs, et al.
Publicado: (2022)

Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing
por: Harihar, Sitaram, et al.
Publicado: (2014)

Change of guard at ACTN
por: Hoke, Ahmet
Publicado: (2023)

High ACTN1 Is Associated with Poor Prognosis, and ACTN1 Silencing Suppresses Cell Proliferation and Metastasis in Oral Squamous Cell Carcinoma
por: Xie, Guo-feng, et al.
Publicado: (2020)

TIP60 acts as a regulator of genes involved in filopodia formation and cell migration during wound healing
por: Dubey, Shraddha, et al.
Publicado: (2022)

Filopodia-based contact stimulation of cell migration drives tissue morphogenesis
por: Bischoff, Maik C., et al.
Publicado: (2021)

Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice
por: Grieb, Brian C., et al.
Publicado: (2016)

Filopodia motor ahead
por: Leslie, Mitch
Publicado: (2007)

Viruses infect filopodia
por: LeBrasseur, Nicole
Publicado: (2007)

The Finer Points of Filopodia
por: Lundquist, Erik A.
Publicado: (2009)

Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration
por: Nishita, Michiru, et al.
Publicado: (2006)

Fascin promotes filopodia formation independent of its role in actin bundling
por: Zanet, Jennifer, et al.
Publicado: (2012)

Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation
por: Dobramysl, Ulrich, et al.
Publicado: (2021)

Dynamics of Endothelial Engagement and Filopodia Formation in Complex 3D Microscaffolds
por: Ucla, Pierre, et al.
Publicado: (2022)

Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication
por: Kumagai, Akiko, et al.
Publicado: (2020)

MTBP enhances the activation of transcription factor ETS-1 and promotes the proliferation of hepatocellular carcinoma cells
por: Wang, Hongbo, et al.
Publicado: (2022)

Contribution of Filopodia to Cell Migration: A Mechanical Link between Protrusion and Contraction
por: Xue, Fei, et al.
Publicado: (2010)

High Expression Levels of ACTN1 and ACTN3 Indicate Unfavorable Prognosis in Acute Myeloid Leukemia
por: Yang, Xinrui, et al.
Publicado: (2019)

Urge to merge erects filopodia
por: Dove, Alan W.
Publicado: (2003)

Bending membrane to form filopodia
por: Williams, Ruth
Publicado: (2007)

Islands of Conformational Stability for Filopodia
por: Daniels, D. Robert, et al.
Publicado: (2013)

The role of filopodia in the recognition of nanotopographies
por: Albuschies, Jörg, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_s0mqjlklncv1os723kbagv39j2