Cargando…

Reduced Juvenile Long-Term Depression in Tuberous Sclerosis Complex Is Mitigated in Adults by Compensatory Recruitment of mGluR5 and Erk Signaling

Tuberous sclerosis complex (TSC) is a multisystem genetic disease that manifests with mental retardation, tumor formation, autism, and epilepsy. Heightened signaling through the mammalian target of rapamycin (mTOR) pathway is involved in TSC pathology, however it remains unclear how other signaling...

Descripción completa

Detalles Bibliográficos
Autores principales:	Potter, Wyatt B., Basu, Trina, O'Riordan, Kenneth J., Kirchner, Allison, Rutecki, Paul, Burger, Corinna, Roopra, Avtar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742461/ https://www.ncbi.nlm.nih.gov/pubmed/23966835 http://dx.doi.org/10.1371/journal.pbio.1001627

Ejemplares similares

Histone deacetylase inhibitors restore normal hippocampal synaptic plasticity and seizure threshold in a mouse model of Tuberous Sclerosis Complex
por: Basu, Trina, et al.
Publicado: (2019)

Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK
por: Potter, Wyatt B., et al.
Publicado: (2010)

Glu-mGluR2/3-ERK Signaling Regulates Apoptosis of Hippocampal Neurons in Diabetic-Depression Model Rats
por: Liu, Zhuo, et al.
Publicado: (2019)

Group I mGluRs in Therapy and Diagnosis of Parkinson’s Disease: Focus on mGluR5 Subtype
por: Azam, Shofiul, et al.
Publicado: (2022)

Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications
por: Huang, Leyi, et al.
Publicado: (2023)

mGluR5, CB1 and neuroprotection
por: Carvalho, Toniana G., et al.
Publicado: (2016)

The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency
por: Kammermeier, Paul J
Publicado: (2012)

The Changes in mGluR2 and mGluR7 Expression in Rat Medial Vestibular Nucleus and Flocculus Following Unilateral Labyrinthectomy
por: Zhou, Wen, et al.
Publicado: (2013)

Pretreatment with mGluR2 or mGluR3 Agonists Reduces Apoptosis Induced by Hypoxia-Ischemia in Neonatal Rat Brains
por: Bratek - Gerej, Ewelina, et al.
Publicado: (2021)

mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning
por: Harbers, Maria, et al.
Publicado: (2022)

Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression
por: Wood, Christian M., et al.
Publicado: (2018)

mGluR-Dependent Synaptic Plasticity in Drug-Seeking
por: Bellone, Camilla, et al.
Publicado: (2012)

PET imaging of mGluR5 in Alzheimer’s disease
por: Mecca, Adam P., et al.
Publicado: (2020)

Extinction-Dependent Alterations in Corticostriatal mGluR2/3 and mGluR7 Receptors following Chronic Methamphetamine Self-Administration in Rats
por: Schwendt, Marek, et al.
Publicado: (2012)

Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density
por: Gross, Kellie S., et al.
Publicado: (2016)

Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
por: Alese, Oluwole Ojo, et al.
Publicado: (2019)

Target validation: Weak selectivity of LY341495 for mGluR2 over mGluR4 makes glutamate a less selective agonist
por: McCullock, Tyler W., et al.
Publicado: (2019)

Two routes to autism phenotypes via mGluR5
Publicado: (2012)

Translational Concepts of mGluR5 in Synaptic Diseases of the Brain
por: Piers, Thomas M., et al.
Publicado: (2012)

Therapeutic potential of mGluR5 targeting in Alzheimer's disease
por: Kumar, Anil, et al.
Publicado: (2015)

mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia
por: Wang, Hoau-Yan, et al.
Publicado: (2018)

Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem
por: Goel, Nupur, et al.
Publicado: (2020)

Reduced mGluR5 Activity Modulates Mitochondrial Function
por: Gonzalez-Lozano, Miguel A., et al.
Publicado: (2021)

Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD
por: Sanderson, Thomas M., et al.
Publicado: (2022)

Role for Astrocytes in mGluR-Dependent LTD in the Neocortex and Hippocampus
por: Lalo, Ulyana, et al.
Publicado: (2022)

mGluR-dependent plasticity in rodent models of Alzheimer’s disease
por: Valdivia, Gonzalo, et al.
Publicado: (2023)

mGluR5 in amygdala modulates fear memory generalization
por: Xuan, Shou-Min, et al.
Publicado: (2023)

Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors
por: Upreti, Chirag, et al.
Publicado: (2021)

Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro
por: Neyman, Sergey, et al.
Publicado: (2008)

Disrupted mGluR5-Homer scaffolds mediate abnormal mGluR5 signaling, circuit function and behavior in a mouse model of Fragile X Syndrome
por: Ronesi, Jennifer A., et al.
Publicado: (2012)

Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole
por: Liao, Sally, et al.
Publicado: (2017)

Nanoscopic spine localization of Norbin, an mGluR5 accessory protein
por: Westin, Linda, et al.
Publicado: (2014)

Coordination between Translation and Degradation Regulates Inducibility of mGluR-LTD
por: Klein, Matthew E., et al.
Publicado: (2015)

Orchestrated activation of mGluR5 and CB(1) promotes neuroprotection
por: Batista, Edleusa M. L., et al.
Publicado: (2016)

Conformational pathway provides unique sensitivity to a synaptic mGluR
por: Habrian, Chris H., et al.
Publicado: (2019)

Are mGluR2/3 Inhibitors Potential Compounds for Novel Antidepressants?
por: Jiang, Yajie, et al.
Publicado: (2022)

Anti-mGluR1 encephalitis: Case illustration and systematic review
por: Khojah, Osama, et al.
Publicado: (2023)

The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway
por: CHEN, TAO, et al.
Publicado: (2011)

MAGIC: A tool for predicting transcription factors and cofactors driving gene sets using ENCODE data
por: Roopra, Avtar
Publicado: (2020)

mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor α1(ins) subunit in spinal dorsal horn of mice
por: Zhang, Zi-Yang, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tqgt38nu6psdklrouj1rh27uis