Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells

To develop new therapies for inflammatory breast cancer (IBC) we have compared the effects of two hydroxamic acid-based histone deacetylase (HDAC) inhibitors, CG-1521 and Trichostatin A (TSA) on the biology of two IBC cell lines: SUM149PT and SUM190PT. CG-1521 and TSA induce dose (0−10 µM) and time-...

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Detalles Bibliográficos
Autores principales: Chatterjee, Namita, Wang, Wei-Lin Winnie, Conklin, Tucker, Chittur, Sridar, Tenniswood, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742495/
https://www.ncbi.nlm.nih.gov/pubmed/23792638
http://dx.doi.org/10.4161/cbt.25088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742495/
https://www.ncbi.nlm.nih.gov/pubmed/23792638
http://dx.doi.org/10.4161/cbt.25088

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