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Functions of Huntingtin in Germ Layer Specification and Organogenesis

Huntington’s disease (HD) is a neurodegenerative disease caused by abnormal polyglutamine expansion in the huntingtin protein (Htt). Although both Htt and the HD pathogenic mutation (mHtt) are implicated in early developmental events, their individual involvement has not been adequately explored. In...

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Detalles Bibliográficos
Autores principales: Nguyen, Giang D., Molero, Aldrin E., Gokhan, Solen, Mehler, Mark F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742581/
https://www.ncbi.nlm.nih.gov/pubmed/23967334
http://dx.doi.org/10.1371/journal.pone.0072698