Clinical Relevance of Gain-Of-Function Mutations of p53 in High-Grade Serous Ovarian Carcinoma

PURPOSE: Inactivation of TP53, which occurs predominantly by missense mutations in exons 4–9, is a major genetic alteration in a subset of human cancer. In spite of growing evidence that gain-of-function (GOF) mutations of p53 also have oncogenic activity, little is known about the clinical relevanc...

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Detalles Bibliográficos
Autores principales: Kang, Hyo Jeong, Chun, Sung-Min, Kim, Kyu-Rae, Sohn, Insuk, Sung, Chang Ohk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742716/
https://www.ncbi.nlm.nih.gov/pubmed/23967324
http://dx.doi.org/10.1371/journal.pone.0072609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742716/
https://www.ncbi.nlm.nih.gov/pubmed/23967324
http://dx.doi.org/10.1371/journal.pone.0072609

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