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An In Silico Analysis of Troponin I Mutations in Hypertrophic Cardiomyopathy of Indian Origin

Hypertrophic Cardiomyopathy (HCM) is an autosomal dominant disorder of the myocardium which is hypertrophied resulting in arrhythmias and heart failure leading to sudden cardiac death (SCD). Several sarcomeric proteins and modifier genes have been implicated in this disease. Troponin I, being a part...

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Detalles Bibliográficos
Autores principales: Ramachandran, Gayatri, Kumar, Manoj, Selvi Rani, Deepa, Annanthapur, Venkateshwari, Calambur, Narasimhan, Nallari, Pratibha, Kaur, Punit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742764/
https://www.ncbi.nlm.nih.gov/pubmed/23967088
http://dx.doi.org/10.1371/journal.pone.0070704