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STAT3 Regulates MMP3 in Heme-Induced Endothelial Cell Apoptosis
BACKGROUND: We have previously reported that free Heme generated during experimental cerebral malaria (ECM) in mice, is central to the pathogenesis of fatal ECM. Heme-induced up-regulation of STAT3 and CXCL10 promotes whereas up-regulation of HO-1 prevents brain tissue damage in ECM. We have previou...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742773/ https://www.ncbi.nlm.nih.gov/pubmed/23967200 http://dx.doi.org/10.1371/journal.pone.0071366 |