Synthesis and Structure–Activity Relationship Studies of Derivatives of the Dual Aromatase–Sulfatase Inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate and its ortho-halogenated (F, Cl, Br) derivatives are first-generation dual aromatase and sulfatase inhibitors (DASIs). Structure–activity relationship studies were performed on these compounds, and various modifications were ma...

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Detalles Bibliográficos
Autores principales: Woo, L W Lawrence, Wood, Paul M, Bubert, Christian, Thomas, Mark P, Purohit, Atul, Potter, Barry V L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743159/
https://www.ncbi.nlm.nih.gov/pubmed/23495205
http://dx.doi.org/10.1002/cmdc.201300015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743159/
https://www.ncbi.nlm.nih.gov/pubmed/23495205
http://dx.doi.org/10.1002/cmdc.201300015

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