A Prototypical Small-Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production

A high membrane potential across the mitochondrial inner membrane leads to the production of the reactive oxygen species (ROS) implicated in aging and age-related diseases. A prototypical drug for the correction of this type of mitochondrial dysfunction is presented. MitoDNP-SUM accumulates in mitoc...

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Detalles Bibliográficos
Autores principales: McQuaker, Stephen J, Quinlan, Casey L, Caldwell, Stuart T, Brand, Martin D, Hartley, Richard C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743171/
https://www.ncbi.nlm.nih.gov/pubmed/23640856
http://dx.doi.org/10.1002/cbic.201300115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743171/
https://www.ncbi.nlm.nih.gov/pubmed/23640856
http://dx.doi.org/10.1002/cbic.201300115

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