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Structural disorder and the loss of RNA homeostasis in aging and neurodegenerative disease

Whereas many cases of neurodegenerative disease feature the abnormal accumulation of protein, an abundance of recent literature highlights loss of RNA homeostasis as a ubiquitous and central feature of pathological states. In some diseases expanded repeats have been identified in non-coding regions...

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Detalles Bibliográficos
Autores principales: Gray, Douglas A., Woulfe, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743304/
https://www.ncbi.nlm.nih.gov/pubmed/23967011
http://dx.doi.org/10.3389/fgene.2013.00149