Cargando…

Nurr1 Represses Tyrosine Hydroxylase Expression via SIRT1 in Human Neural Stem Cells

Nurr1 is an orphan nuclear receptor best known for its essential role in the development and maintenance of midbrain dopaminergic (DA) neurons. During DA neurogenesis, Nurr1 directly targets human tyrosine hydroxylase (hTH). Here we investigated this targeting to identify the molecular mechanisms by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Tae Eun, Seo, Ji Sun, Yang, Jae Won, Kim, Min Woong, Kausar, Rukhsana, Joe, Eunhye, Kim, Bo Yeon, Lee, Myung Ae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743743/ https://www.ncbi.nlm.nih.gov/pubmed/23977047 http://dx.doi.org/10.1371/journal.pone.0071469

Ejemplares similares

Correction: Nurr1 Represses Tyrosine Hydroxylase Expression via SIRT1 in Human Neural Stem Cells
Publicado: (2014)

Genome-Wide Analysis Identifies NURR1-Controlled Network of New Synapse Formation and Cell Cycle Arrest in Human Neural Stem Cells
por: Kim, Soo Min, et al.
Publicado: (2020)

Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells
por: Paliga, Dennis, et al.
Publicado: (2018)

NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward
por: Logan, Ryan W., et al.
Publicado: (2018)

Nurr1 repression mediates cardinal features of Parkinson’s disease in α-synuclein transgenic mice
por: Argyrofthalmidou, Maria, et al.
Publicado: (2021)

Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension
por: Lee, Yu Ho, et al.
Publicado: (2016)

Pharmacological Stimulation of Nurr1 Promotes Cell Cycle Progression in Adult Hippocampal Neural Stem Cells
por: Moon, Haena, et al.
Publicado: (2019)

Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases
por: Park, Tae-Yoon, et al.
Publicado: (2019)

Quantitative Immunohistochemistry to Measure Regional Expression of Nurr1 in the Brain and the Effect of the Nurr1 Heterozygous Genotype
por: Kummari, Evangel, et al.
Publicado: (2021)

NURR1 Impairment in Multiple Sclerosis
por: Montarolo, Francesca, et al.
Publicado: (2019)

Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXRα heterodimer
por: Zhao, Mohan, et al.
Publicado: (2022)

Restriction of Neural Precursor Ability to Respond to Nurr1 by Early Regional Specification
por: Soldati, Chiara, et al.
Publicado: (2012)

Age-dependent decrease of Nurr1 protein expression in the gerbil hippocampus
por: Ahn, Ji Hyeon, et al.
Publicado: (2018)

Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1
por: Jang, Yongwoo, et al.
Publicado: (2021)

Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins
por: Kang, Hyeog, et al.
Publicado: (2017)

MicroRNA-132 promotes estradiol synthesis in ovarian granulosa cells via translational repression of Nurr1
por: Wu, Shaogen, et al.
Publicado: (2015)

FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase
por: Doan, Khanh V., et al.
Publicado: (2016)

Nurr1 expression is modified by inflammation in microglia
por: Lallier, Scott W., et al.
Publicado: (2016)

PIASγ Enhanced SUMO-2 Modification of Nurr1 Activation-Function-1 Domain Limits Nurr1 Transcriptional Synergy
por: Arredondo, Cristian, et al.
Publicado: (2013)

Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats
por: Qian, Yuan, et al.
Publicado: (2019)

Combined Nurr1 and Foxa2 roles in the therapy of Parkinson's disease
por: Oh, Sang-Min, et al.
Publicado: (2015)

Combined Nurr1 and Foxa2 roles in the therapy of Parkinson's disease
por: Oh, Sang‐Min, et al.
Publicado: (2016)

An optimized Nurr1 agonist provides disease-modifying effects in Parkinson’s disease models
por: Kim, Woori, et al.
Publicado: (2023)

Ferulic Acid Induces NURR1 Expression and Promotes Dopaminergic Differentiation in Neural Precursor Cells
por: Sadeghi-Zadeh, Maryam, et al.
Publicado: (2022)

Molecular characterization and analysis of the porcine NURR1 gene
por: Larsen, Knud, et al.
Publicado: (2016)

NURR1 Downregulation Favors Osteoblastic Differentiation of MSCs
por: Di Benedetto, Adriana, et al.
Publicado: (2017)

Nurr1 Modulation Mediates Neuroprotective Effects of Statins
por: Willems, Sabine, et al.
Publicado: (2022)

The role of NURR1 in metabolic abnormalities of Parkinson’s disease
por: Al-Nusaif, Murad, et al.
Publicado: (2022)

Anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) gene expression in immobilization-stressed rats and PC12 cells
por: Kim, Yangha, et al.
Publicado: (2010)

Correction for Zhao et al., Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXRα heterodimer
Publicado: (2023)

CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis
por: Jang, Min Jun, et al.
Publicado: (2017)

An unusual presentation of tyrosine hydroxylase deficiency
por: Katus, Linn E., et al.
Publicado: (2017)

Human DJ-1-specific Transcriptional Activation of Tyrosine Hydroxylase Gene
por: Ishikawa, Shizuma, et al.
Publicado: (2010)

Altered Nurr1 protein expression in the hippocampal CA1 region following transient global cerebral ischemia
por: Park, Joon Ha, et al.
Publicado: (2020)

The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed
por: Alavian, Kambiz N, et al.
Publicado: (2014)

NURR1 deficiency is associated to ADHD-like phenotypes in mice
por: Montarolo, Francesca, et al.
Publicado: (2019)

Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical Neurons
por: Abdollahi, Mona, et al.
Publicado: (2022)

Advances in NURR1-Regulated Neuroinflammation Associated with Parkinson’s Disease
por: Al-Nusaif, Murad, et al.
Publicado: (2022)

Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation
por: Oh, Mihee, et al.
Publicado: (2020)

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
por: Van Meter, Michael, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9qphl6gipho487et3rk7s8m1no