Conformational Changes in the Lower Palm Domain of ASIC1a Contribute to Desensitization and RFamide Modulation

Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel that contributes to fear and pain as well as neuronal damage following persistent cerebral acidosis. Neuropeptides can affect acid-induced neuronal injury by altering ASIC1a inactivation and/or steady-state desensitization. Yet, e...

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Detalles Bibliográficos
Autores principales: Frey, Erin N., Pavlovicz, Ryan E., Wegman, Clem John, Li, Chenglong, Askwith, Candice C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743763/
https://www.ncbi.nlm.nih.gov/pubmed/23977127
http://dx.doi.org/10.1371/journal.pone.0071733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743763/
https://www.ncbi.nlm.nih.gov/pubmed/23977127
http://dx.doi.org/10.1371/journal.pone.0071733

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